Research Paper Volume 11, Issue 23 pp 11054—11072

EGFR-specific CAR-T cells trigger cell lysis in EGFR-positive TNBC

Figure 7. EGFR-CAR-T cells inhibited high-EGFR-expressing TNBC tumor growth in PDX mouse model. ER, PR, HER2, and EGFR expression in (A) clinical breast cancer samples and (B) breast cancer tumors in PDX mice were assessed in immunohistochemical assays. Compared to con-CAR-T cells, EGFR-CAR-1 and EGFR-CAR-2 T cells decreased breast cancer (C) tumor weights and (D) tumor volumes but did not affect (E) body weights. Error bars represent means ± SEM. T-tests were used for statistical analysis; *p < 0.05, **p < 0.01.