Research Paper Volume 11, Issue 23 pp 11084—11110

α-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice

Figure 2. α-Man blocks MAPKs and NF-κB pathways and activates SIRT3 in eWAT from LPS-treated mice. (A) The expression of iNOS and SIRT3 in eWAT were detected by Western blot analyses. (B) The expression of p-ERK, ERK, p-p38 and p38 were detected by Western blot. (C) The expression of p-IKKα/β, IKKα, IKKβ, p-IκBα, IκBα, p-p65 and p65 were detected by Western blot. α-Tubulin was used as an internal control. Data are expressed as means ± SD (n = 5). #P < 0.05 LPS vs. control, *P < 0.05, LPS + α-Man vs. LPS.