Research Paper Volume 11, Issue 23 pp 11157—11169

A twenty gene-based gene set variation score reflects the pathological progression from cirrhosis to hepatocellular carcinoma

Figure 4. The HGSVA score increased significantly with the progression from cirrhosis to HCC. (A) The HGSVA score in GSE89377. (B) The HGSVA score in GSE6764. (C) The HGSVA score in the TCGA HCC data set (phenotype defined by pathological stage). (D) The HGSVA score in the TCGA HCC data set (phenotype defined by tissue grade). (E) The HGSVA score in GSE6764. (F) ROC results: the AUC is significant, which indicates that the gene set can be used for the early diagnosis of HCC.