Research Paper Volume 11, Issue 23 pp 11186—11201

Active compounds of herbs ameliorate impaired cognition in APP/PS1 mouse model of Alzheimer’s disease

Figure 1. Behavioral performance of animals in the Morris water maze. (A) Average escape latencies. (B) Percentage time spent in the quadrant that previously contained the platform. (C) Number of crossings to the previous location of the platform. (D) Representative swimming paths on day 5 of the place navigation trial were recorded with a video tracking system. (E) familiarity stage (F) exploratory stage. (n=6 per group). Data are presented as the mean± standard error (n=6 per group). (A) P < 0.05, vs. C57; (B) P < 0.05, vs. AD model; (C) P < 0.05, vs. DFO; (D) P < 0.05, vs. Active compounds; (E) P < 0.05, vs. Epimedium; (F) P < 0.05, vs. Astragaoside, (G) P < 0.05, vs. Puerarin. DI = TN/(TN + TF), TN as novel object and TF as familiar objects. discrimination index (DI).