Research Paper Volume 11, Issue 23 pp 11186—11201

Active compounds of herbs ameliorate impaired cognition in APP/PS1 mouse model of Alzheimer’s disease

Figure 5. Effects of the active compounds containing the effective components of Epimedium, Astragaoside and Puerarin on the morphological distribution of the iron uptake protein DMT1-with IRE, DMT1-without IRE, TF, TfR1, iron release protein FPN1, CP, HEPH; iron storage protein Ferritin in the cerebral cortex of AD transgenic mice. All data are expressed as the mean ± SD. Intergroup differences were compared with multivariate analysis of variance followed by the least significant difference test. (A) P < 0.05, vs. C57; (B) P < 0.05, vs. AD model; (C) P < 0.05, vs. DFO; (D) P < 0.05, vs. Active compounds; (E) P < 0.05, vs. Epimedium; (F) P < 0.05, vs. Astragaoside, P < 0.05, vs. Puerarin. (immunohistochemical staining, magnification 200×).