Research Paper Volume 11, Issue 23 pp 11224—11243

Genomic landscapes by multiregion sequencing combined with circulation tumor DNA detection contribute to molecular diagnosis in glioblastomas

Figure 3. Analysis of the subclones and evolution of primary and recurrent GBM samples from patient NO. 05. (A) Four intra-tumor loci from the primary tumor and 5 intra-tumor loci from the recurrent tumor from the same patient were sequenced and analyzed. (B) VAF distribution of different subclone types at each intratumor locus. (C) A clonal evolution map of each intratumor locus. (D) Clonal structure distribution of each intratumor locus. (E) A tumorigenic chart of intratumor loci.