Research Paper Volume 11, Issue 23 pp 11268—11313

The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage

Figure 11. Unbiased analysis of the potential role for RXFP3 in controlling age-related disorders. To test the validity of our hypothesis in an unbiased manner, we used reverse-database analysis using latent semantic indexing platform GeneIndexer. (A) We started by creating a database of proteins, associated with input interrogator terms of the majority of age-related disorders, which we termed the ‘Disease Continuum’. (B) We next tried to identify a potential therapeutic target for these diseases, a GPCR in particular. To do so we investigated the Disease continuum protein dataset with GPCR-related terms, to create the ‘Therapeutic continuum’. (C) The proteins were ranked according to the cosine similarity scores, and based on a correlation ranking probability score (p<0.001, ***) 37 specific proteins were identified demonstrating a large amount of correlation within the therapeutic interrogators greater than the 99th percentile. The top three ranked multidimensional proteins that could represent effective age-related disease targets were, AVPR1B, MAS1 and RLN3, the cognate ligand for the RXFP3.