Research Paper Volume 11, Issue 23 pp 11268—11313

The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage

Figure 8. Investigation of the RXFP3 interactome using Latent Semantic Indexing program, GeneIndexer. Using specific age-related or -unrelated interrogator terms, the Latent Semantic Indexing program, GeneIndexer is able to show a relationship between our dataset and aging. (A) Using Neurodegeneration, cognitive impairment, senescence, Parkinson’s disease, amyotrophic lateral sclerosis, and Alzheimer’s disease as the Age-related interrogation terms (“aging”), and Tuberculosis, spina bifida, asthma, Tourette syndrome, ADHD, achondroplasia, as the unrelated aging terms (“Non-aging”), we were able to support our relationship of RXFP3 with aging (Figure 5). Both for the Control (ctrl) and Stress interactome a stronger correlation was seen with the aging interrogation terms. (B) When the results of the interrogation terms were added together, the difference between the aging and non-aging terms was significant. (C) GeneIndexer output with the cosine similarity score for the proteins with the interrogation terms of the control interactome for RXFP3, and (D) for the stress interactome for RXFP3.