Research Paper Volume 11, Issue 23 pp 11314—11328

CircPTPRA acts as a tumor suppressor in bladder cancer by sponging miR-636 and upregulating KLF9

Figure 7. CircPTPRA overexpression inhibits BC growth in vivo. (A)Tumor growth measurements in mice injected with circPTPRA-overexpressing cells or vector control cells. (B) Representative image of subcutaneous tumors generated in BALB/c nude mice (left), and corresponding tumor weights (right). (C) IHC staining of KLF9 in excised tumors. (D) Schematic diagram depicting the inhibitory effect of circPTPRA on BC cell proliferation by impeding the miR-636/KLF9 interaction. Data are presented as the mean ± SD. **P< 0.01(Student’s t-test).