Figure 2. Establishment of prognostic gene signature by LASSO regression analysis. LASSO coefficient profiles of the 25 genes in TCGA-LUAD (A) and 11 genes in TCGA-LUSC (B). A coefficient profile plot was generated against the log (lambda) sequence. Selection of the optimal parameter (lambda) in the LASSO model for TCGA-LUAD (C) and TCGA-LUSC (D). (E) Genetic alteration of the 22 genes in the TCGA-LUAD cohort (TCGA, Provisional). (F) Genetic alteration of the 11 genes in the TCGA-LUSC cohort (TCGA, Provisional).