Research Paper Volume 11, Issue 23 pp 11440—11462

Prognostic implications of autophagy-associated gene signatures in non-small cell lung cancer

Figure 4. Autophagy-associated gene signature was significantly related to survival in lung cancer. (AB) Multivariate Cox regression analysis. The autophagy-associated gene signature was an independent predictor of prognosis in TCGA-LUAD (A) and TCGA- LUSC (B). (CD) Kaplan-Meier analysis of TCGA lung cancer patients stratified by the median risk score. (C) The high risk scores were related to poor overall survival in TCGA-LUAD. (D) The high risk scores were correlated with poor overall survival in TCGA-LUSC. (EF) Receiver operating characteristic (ROC) analysis of the sensitivity and specificity of the OS for the 22-gene risk score in TCGA-LUAD (E) and 11-gene risk score in TCGA-LUSC (F). The combination of stage and risk score could better predict prognosis in TCGA-LUAD (G) and TCGA-LUSC (H) than either one alone.