Research Paper Volume 11, Issue 23 pp 11520—11540

Bone morphogenetic protein 4 (BMP4) alleviates hepatic steatosis by increasing hepatic lipid turnover and inhibiting the mTORC1 signaling axis in hepatocytes

Figure 7. BMP4 may suppress hepatic steatosis and alleviate the development and progression of NAFLD by inhibiting mTORC1 signaling. BMP4 decrease the expression of S6K, p-S6K and SREBF1, while increase the expression of LIPIN1.