Review Volume 11, Issue 24 pp 12844—12861

Targeting senescent cells: approaches, opportunities, challenges

Figure 2. Treatment with senolytics to specifically kill senescent cells (1). Over time, these apoptotic bodies will be cleared by the immune system (2). Finally, a regenerative process will lead to normal tissue functions (3). Normal cells could be affected by either the lack of specificity of the senolytics or chronic treatment, leading to tissue dysfunction (4).