Review Volume 11, Issue 24 pp 12844—12861

Targeting senescent cells: approaches, opportunities, challenges

Figure 5. Inducing senescence in tumor cells will lead to an accumulation of senescence burden (1). The pro-inflammatory and pro-tumorigenic environment (more SASP factors) leads to exacerbation of the pathology (e.g. cancer relapse, fibrosis, inflammation) (2, 3). By targeting senescent cells with a combination of the approaches currently used, a better final scenario is possible (4). Fibrotic scarring may be treated by other means, or cured over time.