Research Paper Volume 11, Issue 23 pp 11591—11608

Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer’s disease mouse model

Figure 1. Results of the OFT, DI of the NORT, and DI of the OLT in male mice at 8-month-old Wt Control, 5XFAD Control, and 5XFAD treated with UNC0642 (5mg/Kg) mice groups. Locomotor Activity (A), Rearings (B), and Groomings (C). For NORT: Summary of the short-term memory (D), and long-term memory (E). Summary of DI (F). Values represented are the mean ± Standard error of the mean (SEM); (n = 27 (Wt Control n = 10, 5XFAD Control = 10, 5XFAD UNC0642 n = 7)). *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.