Research Paper Volume 11, Issue 23 pp 11591—11608

Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer’s disease mouse model

Figure 2. Global 5-methylated (A), and 5-hydroxymethylated cytosine levels (B) in the hippocampus from different mice groups. Representative Western Blot, and quantification for H3K9me2 (C). Values in bar graphs are adjusted to 100% for protein levels of the Wt Control. Values represented are mean ± Standard error of the mean (SEM); (n = 12 (Wt Control n = 4, 5XFAD Control = 4, 5XFAD UNC0642 n = 4)). *p<0.05.