Research Paper Volume 11, Issue 23 pp 11591—11608

Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer’s disease mouse model

Figure 3. Representative WB, and quantification for NRF2 (A), SOD1 (C), and GPX1 (D). Representative gene expression for Hmox1 (B). Representative OS measured as hydrogen peroxide concentration in homogenates of the hippocampus tissue (E). Values in bar graphs are adjusted to 100% for protein levels of the Wt Control. Gene expression levels were determined by real-time PCR. Values represented are mean ± Standard error of the mean (SEM); (n = 3-6 for each group). *p<0.05; **p<0.01.