Research Paper Volume 12, Issue 1 pp 53—69

FHL3 promotes pancreatic cancer invasion and metastasis through preventing the ubiquitination degradation of EMT associated transcription factors

Figure 1. FHL3 referred to PDAC progression. (A and B) IHC staining and statistical analysis of FHL3 for sections from 55 matched different lesion stages tissues of PDAC and para-tumor normal area, which showed the higher expression level of FHL3 in PDAC, more than 3-fold, as compared with normal tissue, p<0.001. (C) Survival analysis via Kaplan-Meier analysis in 55 PDAC samples which showed higher expression level of FHL3 was accompanied with worse prognosis, p=0.0168. (D) WB assay of 8 matched fresh frozen PDAC samples, which showed higher expression level of FHL3 in PDAC tissues more than 1.5-fold, p<0.01.