Research Paper Volume 11, Issue 24 pp 12246—12269

Development and validation of a nomogram with an autophagy-related gene signature for predicting survival in patients with glioblastoma

Figure 1. Identification of differentially expressed autophagy-related genes (DE-ATGs) in glioblastoma (GBM) and enrichment analysis. (A) Volcano plot of DEGs in tumor and normal samples of The Cancer Genome Atlas (TCGA) dataset. The vertical axis indicates the -log (adjusted P value [adj. P value]), and the horizontal axis indicates the log2 (fold change [FC]). The red dots represent upregulated genes, and the green dots represent downregulated genes (adj. P value <0.01 and |log2(FC)|>1). (B) Venn diagram showing the 72 DE-ATGs (the intersection of the DEGs and ATGs). (C) Biological processes enriched in the DE-ATGs. (D) Cellular components enriched in the DE-ATGs. (E) Molecular functions enriched in the DE-ATGs. (F) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enriched in the DE-ATGs.