Research Paper Volume 11, Issue 23 pp 11640—11658

Specific DNA methylation markers in the diagnosis and prognosis of esophageal cancer

Figure 1. Diagnostic methylation classifier can differentiate for NSE, BE, EAC, and ESCC. Unsupervised hierarchical clustering and heatmap of 12 methylation markers selected for constructing diagnostic methylation classifier in (A) training (N=377), (C) test (N=187), and (E) validation set (N=184). ROC curve showing the high AUC in predicting four tissue types in (B) training, (D) test, and (F) validation set.