Research Paper Volume 11, Issue 24 pp 12375—12411

Discovering master regulators in hepatocellular carcinoma: one novel MR, SEC14L2 inhibits cancer cells


Figure 1. Schematic representation of MR discovery and validation in HCC datasets. (A) Different HCC-related gene expression datasets were analyzed in parallel with the ARACNe-MRA pipeline. (B) MRA agreement among different cohorts using unfiltered networks. The scatter plots show ranking agreement (by enrichment P-values) for all regulons between the different cohorts. Each dot represents one regulon (MR and all its targets) in the TN. The correlation coefficient R is given for each pairwise ranking. An UpSet plot of the intersection of identified regulons in different cohorts is presented in the right panel.