Research Paper Volume 12, Issue 1 pp 80—105

Ubenimex induces autophagy inhibition and EMT suppression to overcome cisplatin resistance in GC cells by perturbing the CD13/EMP3/PI3K/AKT/NF-κB axis

Figure 4. Ubenimex enhances CDDP efficacy in cell-based xenografts by inhibiting CD13 expression. (A) Tumor presentations in killed mice from each group were demonstrated. (B, C) The tumor volume (B) and tumor weight (C) with the means±SD from three independent experiments were evaluated. *P<0.05,**P<0.01 and #P>0.05 versus PBS, CDDP and Ube/CDDP group. (D) CD13 expression in tumor specimens of each group was assessed by Western blot assay. The results are demonstrated as the representatives (left panels) and the relative expression with the means±SD (right panel) from three irrelevant experiments. **P<0.01 versus PBS, CDDP and Ube/CDDP group.