Figure 9. Schematic showing that under condition of non-oxidative stress, Nrf2 binds to Keap1 and promotes ubiquitination of Nrf2. Oxidative stress induces PRDX5 expression. Up-regulated PRDX5 competes with Keap1 for binding Nrf2 and inhibits ubiquitination of Nrf2 by Keap1. Up-regulation of Nrf2-ARE signaling pathway can promote proliferation and reduce apoptosis of NSCLC.