Research Paper Volume 12, Issue 1 pp 156—177

Over-expression of EGFR regulated by RARA contributes to 5-FU resistance in colon cancer

Figure 2. The expression of ATG genes is associated with clinically actionable genes in cancer cell lines. (A) Correlation between the expression of ATG genes and clinically actionable genes (CAGs). Blue, negative correlation; red, positive correlation. Bold boxes highlight the protein-protein interactions of actionable genes and ATG genes based on HPRD. The x marks transcription factor (TF)-target relationships for CAGs and ATG genes. Color bars indicate the PCC between drugs and autophagy genes. (B) Sub-network by PCC |R| > 0.3; p <0.05. Orange, CAGs; Blue, autophagy genes. The width of the edge represents the PCC (the bolder the higher).