Figure 4. COL4A1 and COL4A2 genomic alterations, correlation, and signaling pathway in HCC (cBioPortal). (A) Heat map showing the genomic alteration types and expression of COL4A1 and COL4A2 in HCC tissues (n=371). The genomic alterations are highlighted in different markers. One column represents one individual. (B) Correlation analysis showing the significant positive correlation between COL4A1 and COL4A2. (C) COL4A1 and COL4A2 shared a bidirectional promoter, which was regulated by the downstream activating element. (D) Network showing the COL4A1/COL4A2 (with a bold border) and their neighboring genes with alteration frequencies >10% in HCC. PTK2 (in darker red) was the most frequently altered neighbor gene (46.4%). The brown connection shows that these genes are involved in the same biological component, such as a complex. The blue connection shows that the first gene causes a state change, such as a phosphorylation change, within the second gene.