Research Paper Volume 11, Issue 24 pp 12810—12821

Nicotine instigates podocyte injury via NLRP3 inflammasomes activation

Figure 2. Nicotine induced NLRP3 inflammasome formation in podocytes. (A) Representative confocal fluorescence images show the colocalization of NLRP3 with ASC. (B) Summarized data shows the fold changes of pearson coefficient correlation (PCC) for the colo-calization of NLRP3 with ASC with or without stimulation of nicotine and/or caspase-1 inhibition by WEHD. N=5. Veh: Vehicle. *significant difference from control, # significant difference from nicotine treated group.