Research Paper Volume 12, Issue 1 pp 436—461

Aging exacerbates neutrophil pathogenicity in ischemic stroke

Figure 2. Aged animals experience smaller infarcts, poorer neurological deficits and equivalent neutrophil infiltration than young animals following ischemic stroke. Young (3 month) and aged (24 month) mice were subjected to 60-minute MCAO. (A) Infarct volumes by TTC 24 hours post-stroke, n=7-11/group, presented as mean +/- SEM. (B) Stroke mortality rates, n=5/group, (C) Weight loss as a % of starting weight, n=5/group (D) Neurodeficit scores, n=5/group. (E) Absolute quantification of brain-infiltrating neutrophils in sham and stroke animals 24 hours after stroke onset, (F) Representative flow plots. SSC=Side Scatter. n=3/sham group, 4/stroke group. *p≤0.05, **p=<0.01, ***p=<0.001.