Research Paper Volume 12, Issue 1 pp 436—461

Aging exacerbates neutrophil pathogenicity in ischemic stroke

Figure 6. Anti-Ly6G treatment does not improve long-term mortality, neurological deficits or behavioral testing in young mice after stroke. Young (3 month) mice were subjected to 60 minute MCAO, and received either 500ug of anti-Ly6G or 500ug of isotype control antibody I.P. at 4, 24 and 48 hours after stroke (n=6-7/group). (A) Post stroke mortality was monitored out to 56 days post-stroke. (B) Neurological deficits were measured at 7, 14, 21, 28 and 56 days post-stroke. (C) Serial corner testing at day 7, 14 and 56 post-stroke in young mice after MCAO. (D) Hang-wire strength testing in young mice after MCAO at day 7. N=6-7/group.