Research Paper Volume 12, Issue 1 pp 436—461

Aging exacerbates neutrophil pathogenicity in ischemic stroke

Figure 7. Anti-Ly6G treatment improves gross neurodeficit recovery after stroke in aged mice. N=9/group. Mortality (A) and neurological deficit score (B) were assessed in aged (21-22 month) male mice receiving 500ug of anti-Ly6G or isotype control antibody at 4, 24 and 48 hours after stroke. Behavioral testing of aged mice receiving anti-Ly6G or control antibody after ischemic stroke, including corner test (C), adhesive test (D) and hangwire test (E). *p≤0.05, **p=<0.01, ***p=<0.001, ****p=<0.0001.