Research Paper Volume 12, Issue 1 pp 543—570

Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway

Figure 1. Activation of α7 nAChR attenuates apoptosis induced by Aβ oligomers. (A) The primary hippocampus cell group (Control), (B) the primary hippocampus cells treated with PNU (PNU), (C) the primary hippocampus cell treated with MLA (MLA), (D) the primary hippocampus cell treated with Aβ (Aβ), (E) the primary hippocampus treated with PNU and Aβ (PNU+Aβ), (F) the primary hippocampus treated with MLA and Aβ (MLA+Aβ) and (G) a histogram presenting the apoptotic death rates of the different groups. (C and D) The apoptosis rate of primary neuronal cells treated with MLA and Aβ oligomers was significantly increased, (E) while α7 nAChR attenuated apoptosis induced by Aβ oligomers. Data are presented as the mean ± standard deviation. *P<0.05, **P<0.01 vs. control group; #P<0.05, ##P<0.01 vs. Aβ group.