Figure 3. Discrimination capacity of amyloid accumulation and lysosomal/mitochondrial cholesterol carriers. ROC curves of immunolabel for Aβ42, NPC1, and StARD1 in each hippocampal region with the significantly highest AUC resulted in the comparison between control and AD, DS, or AD+DS groups (Lower panel). Red dots show the cutoff for the corresponding IHC-immunolabel that better discriminate AD and/or DS condition from normal controls in each hippocampal region. (*) p<0.05; (**) p<0.01; (***) p<0.001.