Research Paper Volume 12, Issue 1 pp 628—649

Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice

Figure 6. Effect of L. plantarum supplementation on long-term potentiation (LTP) decline in APP/PS1 mice. The population spike (PS) amplitudes and LTP induction were recorded in WT and APP/PS1 mice (A). Summary of average PS amplitude (31-90 minutes) from all experiments shown in A (B). ***P<0.001, versus the WT mice, by unpaired Student's t-tests. #P<0.05, ##P<0.01, ###P<0.001, versus the APP/PS1 mice, by one-way ANOVA analysis followed by Dunnett’s post hoc test. All values are mean ± S.D. n=15. W=wild type; Mem=memantine; LP=L. plantarum.