Research Paper Volume 12, Issue 1 pp 628—649

Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice

Figure 7. Effect of L. plantarum supplementation on Αβ deposition in APP/PS1 mice. Representative immunofluorescence staining images showing Αβ plaques (green and indicated by red arrows) in the hippocampus of WT and APP/PS1 mice (A). Quantitative analysis of Αβ plaques (B), Aβ1-40 (C) and Aβ1-42 (D) in the hippocampus was used by Image Pro Plus 6.0 software and AlphaLISA assay. ***P<0.001, versus the WT mice, by unpaired Student's t-tests. #P<0.05, ##P<0.01, versus the APP/PS1 mice, by one-way ANOVA analysis followed by Dunnett’s post hoc test. All values are mean ± S.D. n=15. WT=wild type; Mem=memantine; LP=L. plantarum.