Research Paper Volume 12, Issue 1 pp 628—649

Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice

Figure 8. Effects of L.plantarum supplementation on hippocampal neuron and plasticity in APP/PS1 mice. Representative images of Nissl staining images (upper panel) and dendritic spines (lower panel) under microscopy in the hippocampus of WT and APP/PS1 mice (A). Quantification of and Nissl bodies (B) and mean dendritic spine density (C). The expression of hippocampal synaptophysin (D) and PSD95 protein (E). ***P<0.001, versus the WT mice, by unpaired Student's t-tests. #P<0.05, ##P<0.01, versus the APP/PS1 mice, by one-way ANOVA analysis followed by Dunnett’s post hoc test. All values are mean ± S.D. n=15. WT=wild type; Mem=memantine; LP=L. plantarum.