Priority Research Paper Volume 12, Issue 1 pp 8—34

Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity

Figure 7. Resveratrol enhances the susceptibility to T-cell-mediated tumor cell killing. T-cell-mediated cell death of JIMT-1 cells pre-cultured in the absence of presence of RSV was measured using the xCELLigence system. Shown are the mean (±SD, n=3) of % lysis values calculated from the impedance-based lysis assay at 5 and 10 hours following the addition of T-cells. Also shown are microphotographs of representative T-cell-mediated cancer cell killing assays in which tumor cells were subjected to crystal violet staining. Statistical analysis was performed using GraphPad Prism 7, using two-way ANOVA with Sidak’s multiple comparison post-test, comparing untreated versus RSV-treated per time (* = P < 0.01).