Research Paper Volume 12, Issue 1 pp 672—689

Up-regulation of microRNA-375 ameliorates the damage of dopaminergic neurons, reduces oxidative stress and inflammation in Parkinson’s disease by inhibiting SP1

Figure 3. Detection of dopamine content in striatum of rats in each group (n = 12). (A) Dopamine content in the striatum of rats; (B) Dopamine content in the striatum of rats in the normal group was measured by HPLC; (C) Dopamine content in the striatum of rats in the model group was measured by HPLC; * P < 0.05 vs the normal group; # P < 0.05 vs the mimics NC group; & P < 0.05 vs the miR-375 mimics group. The measurement data were expressed as mean ± standard deviation and ANOVA was used for the comparison among multiple groups. After ANOVA analysis, the Tukey’s post-hoc test was used for pairwise comparison.