Research Paper Volume 12, Issue 1 pp 672—689

Up-regulation of microRNA-375 ameliorates the damage of dopaminergic neurons, reduces oxidative stress and inflammation in Parkinson’s disease by inhibiting SP1

Figure 9. SP1 is determined as a target gene of miR-375. (A) TargetScan prediction of target site for SP1 and miR-375; (B) Detection of the luciferase activity by dual luciferase reporter gene assay; the independent experiment was repeated 3 times. The data represent the mean ± standard deviation of three independent experiments.