Research Paper Volume 12, Issue 1 pp 718—739

Integrated transcriptome expression profiling reveals a novel lncRNA associated with L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease

Figure 3. Expression profiles of the lncRNA NONRATT023402.2. (A) Validation of RNA sequencing results by qRT-PCR-based quantification of 10 lncRNAs from profile 3 (n = 3). (B) (Up) NONRATT023402.2 expression in the striatum of PD and LID rats and their corresponding control groups detected by qRT-PCR (n = 6–11). (Down) Pearson’s correlation coefficient between NONRATT023402.2 expression in the striatum of LID rats and AIM score (n = 11). (C) qRT-PCR analysis of NONRATT023402.2 levels in the SN, M1, and contralateral striatum of PD and LID rats and their corresponding controls (n = 6–11). (D) FISH labeling of NONRATT023402.2 in the striatum of rats. Arrows and asterisks indicate neurons and astrocytes, respectively. Data represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.