Research Paper Volume 12, Issue 1 pp 740—755

Network analysis of human muscle adaptation to aging and contraction


Figure 3. Molecular networks and candidate molecules of the aging muscle contractile response. Modules shown are those with a co-expression profile responsive to ECC and/or CON contraction in young adults, older adults or both. Red and blue shading denote significant post-exercise upregulation and downregulation relative to baseline (BL), respectively (FDR < 5%). Also provided is each such module’s top ranked hub gene, and their enriched transcription factor binding sites (TFBS). Red dots/ connecting red lines indicate whether a TFBS is enriched in the genes of one or more contraction-induced module.