Figure 3. Widespread cancer-associated mutations in tumor and normal tissues. (A) Distribution of mutations in genes we selected in the seven CRC patients; the grayscale reflects the frequency of mutations. (B) Wayne diagram of the distribution of mutated genes in patients. (C) Distribution of mutated genes in the seven CRC patients. (D) Distribution of deletion and substitution mutations in the seven patients. (E) Distribution of subdivided substitutions in the seven patients. (F) Distributions of mutant genes in tissue samples from the central peripheral regions of the tumors in the seven CRC patients. (G) Distributions of mutant genes in samples from T1 tumors and normal colonic tissue from the seven CRC patients.