Research Paper Volume 12, Issue 1 pp 844—865

Surgery/Anesthesia disturbs mitochondrial fission/fusion dynamics in the brain of aged mice with postoperative delirium

Figure 3. Surgery/Anesthesia decreased the DISC1 expression in the hippocampus and prefrontal cortex of aged mice at postoperative 0, 6, 9, and 24 hours. The expression of DISC1 was estimated using western blotting analysis of fresh homogenates from hippocampal and prefrontal cortex tissues of mice at 0, 6, 9, and 24 hours after Surgery/Anesthesia or control treatment. (A and C) The level of DISC1 in the hippocampus of mice in the Surgery/Anesthesia group decreased significantly compared to that in control mice at postoperative 0, 6, 9, and 24 hours. (B and D) The level of DISC1 in the prefrontal cortex tissue of mice in the Surgery/Anesthesia group decreased significantly compared to that in control mice at postoperative 0, 6, 9, and 24 hours. The data are plotted as the mean ± standard error of the mean for each group (n = 6). *p < 0.05 and **p < 0.01, compared to control.