Research Paper Volume 12, Issue 1 pp 866—883

Prognostic value of epithelial-mesenchymal transition markers in clear cell renal cell carcinoma

Figure 5. CDH1, CDH2, SNAI1, SNAI2 and TWIST1 significantly involved in stromal process of ccRCC tumor environment. EMT makers, including CDH1 (A), CDH2 (B), SNAI1 (C), SNAI2 (D), TWIST1 (F), but not VIM (E), showed significant correlation with stromal process in ccRCC environments (p<0.001). In addition, CDH1 showed negative association with stromal score (r2=-0.191), while stromal score positively correlated CDH2 (r2=0.337), SNAI1 (r2=0.199), SNAI2 (r2=0.201) and TWIST1 (r2=0.305) mRNA expression in ccRCC patients from TCGA cohort.