Research Paper Volume 12, Issue 4 pp 3126—3139

LncRNA AK045171 protects the heart from cardiac hypertrophy by regulating the SP1/MG53 signalling pathway

Figure 7. Schematic showing the possible molecular mechanism underlying the effect of AK045171 in TAC- and Ang II-induced cardiac hypertrophy. AK045171 binds with SP1 and activates MG53 transcription. MG53 inhibits nuclear transfer of p65 and β-catenin, thereby decreasing expression of their downstream target genes, such as ANP, BNP and β-MHC.