Figure 5. Comparison with other prognostic signatures and clinical characteristics. We calculated continuous prediction scores based on five other disease prognostic signatures and compared the different datasets using a univariate Cox model. (A) Mean C-index of IPSHCC, age, stage, gender, tumor invasion, and 5 reported signatures. Among 10 survival predictors, IPSHCC had the highest mean C-index (0.709) compared to age (0.526), stage (0.673), invasion (0.571), and gender (0.542). (B) P value comparison of IPSHCC and 5 reported signatures. Red block indicates the model is significant (P ≤ 0.05) while black indicates lack of significance (P > 0.05). IPSHCC demonstrated the lowest p-value among survival predictors (p = 9.22 × 10-7) across datasets.