Figure 4. The shared and unique metabolic signature between male and female patients with SCLC. (A) The common and unique disturbed pathways in male and female SCLC compared to NSCLC and controls. (B) Total 2-hydroxy (2-OH) ceramides were significantly higher in male SCLC, while, no differences were observed in female patients with SCLC. (C) Total unsaturated PE was dramatically lower in female SCLC without significant changes in male SCLC. One-way ANOVA followed by Tukey’s test. * P < 0.05 and ns: nonsignificant. Abbreviations: NSCLC = non-small cell lung cancer; PE = phosphatidylethanolamine; SCLC = small cell lung cancer.