Research Paper Volume 12, Issue 6 pp 4711—4726

Silencing of lncRNA XIST inhibits non-small cell lung cancer growth and promotes chemosensitivity to cisplatin

Figure 5. SMAD2 knockdown rescues the effect of XIST inhibition on the proliferation and survival of NSCLC cells. Proliferation of NSCLC cells evaluated by (A) MTT assay and (B) EDU staining. (C) Colony formation assay results. (D) Apoptosis detection by annexin V/PI staining and flow cytometry. (E) Cell viability under different concentrations of DDP was evaluated. (F) After transfection, the inhibition rate of DDP on NSCLC cells was assessed. * < 0.05 vs si-XIST group.