Research Paper Volume 12, Issue 2 pp 1656—1684

Elevated lymphocyte specific protein 1 expression is involved in the regulation of leukocyte migration and immunosuppressive microenvironment in glioblastoma

Figure 3. LSP1 exhibited the potential as a molecule for predicting radiotherapeutic and chemotherapeutic response in GBM. (A and B) Kaplan-Meier curves describing the association between LSP1 expression and the survival of GBM patients treated with or without radiotherapy (A, CGGA RNA sequencing dataset; B, TCGA RNA sequencing dataset; with log-rank test). (C) Kaplan-Meier curve describing the correlation between LSP1 expression and the survival of GBM patients with different MGMT promoter status in TCGA RNA sequencing dataset (with log-rank test). (D) Kaplan-Meier curve describing the correlation between LSP1 expression and the survival of GBM patients receiving chemotherapy in TCGA RNA sequencing dataset (with log-rank test). ns, *, **, *** and **** indicate no significance, P < 0.05, P < 0.01, P < 0.001, and P < 0.0001, respectively. CGGA, Chinese Glioma Genome Atlas; TCGA, The Cancer Genome Atlas; GBM, glioblastoma multiforme; LSP1, lymphocyte specific protein 1; MGMT, O6-methylguanine-DNA methyltransferase.