Research Paper Volume 12, Issue 2 pp 1656—1684

Elevated lymphocyte specific protein 1 expression is involved in the regulation of leukocyte migration and immunosuppressive microenvironment in glioblastoma

Figure 4. Functional enrichment analysis revealed that LSP1 was associated with immunologic events. (A and B) The results of GO analysis describing biological processes associated with LSP1 positive-correlated genes in GBM (A, CGGA RNA sequencing dataset; B, TCGA RNA sequencing dataset). Bubble diameter: enrichment gene counts; abscissa: -log 10 P-value (P < 0.05). (C and D) The GO terms correlated with high LSP1 expression in GBM by GSVA (C, CGGA RNA sequencing dataset; D, TCGA RNA sequencing dataset). (E) The results of GSEA indicating a significantly enhanced leukocyte migration in GBM with high LSP1 expression (upper panel, CGGA RNA sequencing dataset; lower panel, TCGA RNA sequencing dataset; P < 0.05 and FDR < 0.01). (F) The LSP1 related pathways revealed by 892 overlapping LSP1 positively related genes in CGGA and TCGA RNA sequencing datasets with ClueGO. CGGA, Chinese Glioma Genome Atlas; TCGA, The Cancer Genome Atlas; GBM, glioblastoma multiforme; LSP1, lymphocyte specific protein 1.