Figure 4. Functional enrichment analysis revealed that LSP1 was associated with immunologic events. (A and B) The results of GO analysis describing biological processes associated with LSP1 positive-correlated genes in GBM (A, CGGA RNA sequencing dataset; B, TCGA RNA sequencing dataset). Bubble diameter: enrichment gene counts; abscissa: -log 10 P-value (P < 0.05). (C and D) The GO terms correlated with high LSP1 expression in GBM by GSVA (C, CGGA RNA sequencing dataset; D, TCGA RNA sequencing dataset). (E) The results of GSEA indicating a significantly enhanced leukocyte migration in GBM with high LSP1 expression (upper panel, CGGA RNA sequencing dataset; lower panel, TCGA RNA sequencing dataset; P < 0.05 and FDR < 0.01). (F) The LSP1 related pathways revealed by 892 overlapping LSP1 positively related genes in CGGA and TCGA RNA sequencing datasets with ClueGO. CGGA, Chinese Glioma Genome Atlas; TCGA, The Cancer Genome Atlas; GBM, glioblastoma multiforme; LSP1, lymphocyte specific protein 1.