Research Paper Volume 12, Issue 3 pp 2070—2083

Mitochondria and aging in older individuals: an analysis of DNA methylation age metrics, leukocyte telomere length, and mitochondrial DNA copy number in the VA normative aging study

Figure 2. Associations of baseline Mitochondrial DNA Copy Number (mtDNAcn) with prospective measures of DNA Methylation Age (DNAm-Age), DNAm-PhenoAge, DNAm-GrimAge, and Telomere Length. The effect estimates (β) and corresponding 95% confidence intervals were estimated with linear mixed models adjusted for chronological age, measure at baseline, smoking, alcohol use, BMI, hypertension status, CHD status, diabetes status, blood cell type composition, and follow up time.