Figure 3. Significantly enriched pathways associated with EP300 mutation. Gene set enrichment analysis has been performed with TCGA. Gene enrichment plots shows that a series of gene sets including (A) Biocarta IL2 Pathway, (B) Biocarta Insulin Pathway, (C) Kegg Natural Killer Cell Mediated Cytotoxicity, (D) Pid IL12 Stat4 Pathway, (E) Reactome Cytokine Signaling in Immune System, and (F) Reactome MHC II Antigen Presentation are enriched in EP300-mutant group. NES, normalized enrichment score. The p-value is marked in each plot.